The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening
نویسندگان
چکیده
منابع مشابه
Fecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer.
BACKGROUND Colorectal cancer (CRC) is a disease with major impact on public health and public health costs. Colonoscopy is purportedly the best screening tool for CRC. However, the acceptance by the general population is very poor. Therefore evaluation of additional screening tools is of great interest. PATIENTS AND METHODS The use of M2-PK measurement in the feces has been reported in 6 stud...
متن کاملThe value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
AIM to evaluate the performance of fecal tumor M2 pyruvate kinase (M2PK) as a diagnostic biomarker for colorectal cancer (CRC) screening in high-risk or symptomatic populations. METHODS consecutive patients (N=328) who were referred for elective colonoscopy were prospectively enrolled. One walnut-sized stool sample was collected from each patient for analysis of tumor M2PK content using an EL...
متن کاملEvaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer
BACKGROUND Expression of the dimeric M2 isoenzyme of pyruvate kinase, termed Tumor M2-PK, is increased in some human cancers. This study evaluates the potential role of pre-operative Tumor M2-PK as a marker of prognosis in patients with pancreatic malignancy. METHODS Seventy-three consecutive patients with a clinical diagnosis of pancreatic or peri-ampullary cancer were enrolled. Their median...
متن کاملThe Usefulness of a Novel Screening Kit for Colorectal Cancer Using the Immunochromatographic Fecal Tumor M2 Pyruvate Kinase Test
BACKGROUND/AIMS M2 pyruvate kinase (M2-PK) is an enzyme that is produced in undifferentiated and proliferating tissues. This study aims to evaluate the usefulness of the immunochromatographic M2 pyruvate kinase (iM2-PK) for the screening of colorectal cancer (CRC) and premalignant lesions. METHODS Healthy volunteers and patients with colorectal neoplasia were enrolled in six academic hospital...
متن کاملColorectal cancer detection in an asymptomatic population: fecal immunochemical test for hemoglobin vs. fecal M2-type pyruvate kinase.
INTRODUCTION Screening programs for colorectal cancer (CRC) are mainly based on a first-line fecal immunochemical test for hemoglobin (FIT). Fecal M2-type pyruvate kinase (M2-PK) has been evaluated in clinical settings showing promising results for early CRC detection. However, the impact of fecal M2-PK assessment on the performance of first-round CRC screening programs is not known. We investi...
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ژورنال
عنوان ژورنال: The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy
سال: 2017
ISSN: 2302-8181,1411-4801
DOI: 10.24871/181201738-42